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BACKGROUND
Conditional survival estimates, which take into consideration the changing risk with increasing survival time, provide a dynamic survival probability and more accurate survival information for clinician decision making. The objective of the current study was to evaluate the conditional disease‐specific survival (DSS) for patients with gastric cancer who underwent curative surgery in China...
BACKGROUND
Although an association between hepatitis C virus (HCV) infection and oropharyngeal cancers (OPCs) has been reported, to the authors' knowledge the clinical significance of this epidemiological finding remains unknown. Therefore, the authors analyzed the oncologic outcomes of HCV‐infected patients with OPCs.
METHODS
In this retrospective cohort study, all patients with OPCs who were...
BACKGROUND
No studies have investigated whether race/ethnicity is associated with the recommended use of preoperative chemotherapy or subsequent outcomes in gastric cancer. To determine whether there is such an association, analyses of patients with gastric cancer in the National Cancer Data Base (NCDB) were performed.
METHODS
Patients with clinical T2‐4bN0‐1M0 gastric adenocarcinoma, as defined...
BACKGROUND
Next‐generation sequencing of cell‐free DNA (cfDNA) has been shown to be a useful noninvasive test for detecting mutations in solid tumors.
METHODS
Targeted gene sequencing was performed with a panel of 263 cancer‐related genes for cfDNA and genomic DNA of peripheral blood mononuclear cells (PBMCs) obtained from presurgical specimens of 6 lung cancer patients, and mutation calls in these...
BACKGROUND
Overall survival (OS) is a critical endpoint in adjuvant trials but requires long durations to events and significant patient resources. In the current study, the authors assessed whether disease‐free survival (DFS) can be an early clinical surrogate for OS in the adjuvant setting for localized renal cell carcinoma (RCC).
METHODS
Using Preferred Reporting Items for Systematic Reviews...
BACKGROUND
Early response to induction chemotherapy is used in current European guidelines to evaluate the efficacy of chemotherapy and subsequently to adapt treatment in pediatric patients with rhabdomyosarcoma (RMS). However, existing literature on the prognostic value of early radiologic response on survival is contradictory; here the prognostic value is analyzed with data from the International...
BACKGROUND
Metastatic biopsies are increasingly being performed in patients with advanced prostate cancer to search for actionable targets and/or to identify emerging resistance mechanisms. Due to a predominance of bone metastases and their sclerotic nature, obtaining sufficient tissue for clinical and genomic studies is challenging.
METHODS
Patients with prostate cancer bone metastases were enrolled...
BACKGROUND
In developed countries, women attend follow‐up after treatment for cervical cancer to detect recurrence. The aim of this study was to describe the Danish population of women with early‐stage cervical cancer at risk for recurrence and death due to recurrence.
METHODS
Data were extracted from 3 nationwide databases to find women diagnosed with stage 1A1 to 1B1 cervical cancer in 2005‐2013...
BACKGROUND
Chemotherapy for early breast cancer is associated with a small risk of developing myelodysplastic syndrome (MDS) and/or acute myeloid leukemia (AML). The aim of this study was to determine the risk of developing AML or MDS after modern adjuvant chemotherapy in older breast cancer patients and to further define the risk of individual chemotherapy regimens.
METHODS
Patients diagnosed...
Thyroid nodules affect nearly two‐thirds of the world population. Fine‐needle biopsy with cytologic evaluation remains the diagnostic test of choice to distinguish benign from malignant thyroid nodules yet fails to discriminate as benign or malignant in up to one‐third of cases. This review discusses the limitation of current cytopathologic evaluation, the development of thyroid molecular testing,...
BACKGROUND
Survivors of childhood cancer are at risk of nonsurgical premature menopause (NSPM). To the authors' knowledge, risk factors for NSPM and its impact on reproduction remain poorly defined.
METHODS
The menopausal status of 2930 survivors diagnosed between 1970 and 1986 (median age, 6 years [range, birth‐20 years]) who were aged > 18 years at the time of the current study (median age,...
BACKGROUND
Screening with the fecal immunochemical test (FIT) is effective in reducing deaths from colorectal cancer (CRC). Since 2004, biennial FIT screening has been available to a target population in Taiwan as a national screening program. The objective of the current study was to identify the factors that influence willingness to undergo a confirmatory colonoscopy after a positive FIT, because...
BACKGROUND
Stereotactic ablative radiotherapy (SABR) is an emerging therapy for primary renal cell carcinoma. The authors assessed safety, efficacy, and survival in a multi‐institutional setting. Outcomes between single‐fraction and multifraction SABR were compared.
METHODS
Individual patient data sets from 9 International Radiosurgery Oncology Consortium for Kidney institutions across Germany,...
BACKGROUND
It is possible that the relative lack of progress in treatment outcomes among adolescent and young adult (AYA) patients with cancer is caused by a difference in disease biology compared with the corresponding diseases in younger and older individuals. There is evidence that colon cancer is more aggressive and has a poorer prognosis in AYA patients than in older adult patients.
METHODS...
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